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KMID : 0370220130570010037
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Yakhak Hoeji
2013 Volume.57 No. 1 p.37 ~ p.42
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Immunoregulatory Effect of Ginsenoside Rd against CD4+ Th lymphocyte
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Joo In-Kyung
Kim Jeong-Hyeon
Omer Shehzad
Kim Yeong-Shik
Han Yong-Moon
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Abstract
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In this present study, we determined the immunoregulatory activity of ginsenoside Rd extract from Panax ginseng. To determine the activity, we tested Rd against CD4+Th cells in a murine model of type 1 diabetes, which involves Th1-dominant immunity. The type 1 diabetes was caused by streptozotocin (STZ) and the severity of the diabetes was evaluated by measuring the degree of hyperglycemia, a major symptom of diabetes. The data resulting from experiments
showed that ginsenoside Rd induced a greater level of Th1 type cytokines [IFN-γ & IL-2] than Th2 type [IL-4 & IL-10] (P<0.05), which was determined by cytokine profile analysis. In the animal model of diabetes, the depletion of CD4+ Th cells by a treatment of anti-CD4 mAb resulted in considerably lower values of blood-glucose levels than those of the mAbuntreated mice, which indicates that the Th1 immune response from CD4+ Th cells are responsible for diabetes. Based on these observations, the effect of Rd on diabetes was examined in the same animal model. Results showed that Rd-treated mice groups had increased levels of blood glucose compared to Rd-untreated mice groups that were used as a negative control (P<0.05). In other words, Rd aggravated the diabetes via the Th1 immune response. In conclusion, ginsenoside Rd had an immunoregulatory activity of Th1-dominant immunity.
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KEYWORD
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immunoregulatory, ginsenoside Rd, diabetes, streptozotocin, CD4+ Th cell, anti-CD4 mAb
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